Reason Behind Complications & Organ Failure In Diabetics

Hyperglycemia Is The Root Cause

Glucose is the basic fuel required by our body cells. But body cells need proper levels of glucose for good functioning. But a very high level of glucose is harmful to body cells.

In diabetics, the abnormally high blood glucose levels damage the body cells by super-oxide overproduction in mitochondria.

Super-oxide oxidizes vital molecules of cells like DNA, and proteins. The image given below shows this effect.

Image credit: The Pathobiology of Diabetic Complications

From Cellular Injuries To Organ Dysfunction

These injuries eventually damage the structure and function of blood vessels of vital organs, like heart, legs, brain, nerves, eyes, and kidney. With time this worsens towards organ dysfunction.

Other coexisting factors like hypertension, obesity, smoking, etc. further aggravate the organ damage and lead to total organ failure. Such patients would require multiple hospitalizations, surgeries, etc. to prolong life.

About the author: Dr. Naval Asija is a licensed MBBS Physician from India. MBBS is the equivalent of the MD degree offered by international medical schools. He is based in Delhi, India, and works as a medical writer, editor, and consultant. He supports medical researches as an author's editor, medical communication companies involved in medico-marketing activities, and medical technology companies in improving their products. He can be contacted via his LinkedIn Profile: https://www.linkedin.com/in/navalasija/

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